Hot flashes from chemotherapy in breast cancer patients is a common side effect. Researchers in this study explored the use of Jia Wei Xiao Yao Wan with Er Zhi Wan (Nu Zhen Zi with Han Lian Cao) and gauged the improvement in both hot flashes and general quality of life scales. The researchers concluded that these formulas "showed a statistically significant reduction in HF frequency at 12 and 24 weeks and a decrease in HF severity at 12 weeks compared to the control group (P < .05) - physical well-being and specific concerns scores also improved significantly over time in the CHM group".